Born in Dadaocheng, Taipei, Kuo Hsueh-hu followed Cai Xuexi in his art education and was given his first name "Hsueh-hu". Kuo was chosen as one of the "Taiten's Up-and-Coming Talents”in Taiwan, along with Lin Yushan and Chen Jin. Kuo practised painting with Gobara Koto and later established his own art studio to promote arts development in Taiwan. Later in his career, he was chosen as one of the adjudicators of the oriental arts group and was given the Cultural Award by the Ministry of Culture of Taiwan in 2007.